She was born into an acting dynasty: All of her paternal great-grandparents – Maurice Barrymore and Georgie Drew Barrymore, and Maurice Costello and Mae Costello (née Altschuk) – as well as her paternal grandparents, John Barrymore and Dolores Costello, were actors; a great-great-granddaughter of Irish-born John Drew and English-born Louisa Lane Drew, all of whom were also actors, and a great-grandniece of Broadway idol John Drew, Jr.and silent film actor, writer and director Sidney Drew.
The same year, she played a young girl divorcing her famous parents in Irreconcilable Differences, for which she was nominated for her first Golden Globe Award for Best Supporting Actress.She endured a troubled youth and continued to act intermittently during the decade.In her late teens, her rebelliousness played itself out on screen and in print.Barrymore forged an image as a manipulative teenage seductress, beginning with Poison Ivy (1992), which was a box office failure, but was popular on video and cable.(In her 2015 memoir Wildflower, she says she talks "like a valley girl" because she grew up in Sherman Oaks.) She moved back to West Hollywood upon becoming emancipated at 14.
In the wake of her sudden stardom, Barrymore endured a notoriously troubled childhood.
for which she earned her second Golden Globe Award nomination.
In 1993, she took on the role of the younger sister of a murdered ballerina in No Place to Hide and starred as a writer followed by what is apparently her evil twin in Doppelganger.
Her first name, "Drew", was the maiden name of her paternal great-grandmother, Georgie Drew Barrymore, and her middle name, "Blythe," was the original surname of the dynasty founded by her great-grandfather, Maurice Barrymore.
Barrymore recounted in her 1989 autobiography, Little Girl Lost, early memories of her abusive father, who left the family when Barrymore was six months old.
Barrymore starred in Far from Home (1989), as a teenager who gets stranded with her father in the small town in a remote part of the desert.