She starred alongside Jeff Bridges and Alice Krige in the 1989 romantic comedy See You in the Morning.Vincent Canby of The New York Times criticized "the fashionable phoniness" of the film, but positively singled out Barrymore for her performance.
Roger Ebert, in his review for the film, wrote for Chicago Sun-Times: "What a good idea, to make a Western about four tough women.And what a sad movie." In 1996, she made a brief but notable appearance in Wes Craven's slasher Scream.for which she earned her second Golden Globe Award nomination.In 1993, she took on the role of the younger sister of a murdered ballerina in No Place to Hide and starred as a writer followed by what is apparently her evil twin in Doppelganger.Barrymore starred in Far from Home (1989), as a teenager who gets stranded with her father in the small town in a remote part of the desert.
The film went largely unnoticed by audiences and received negative reviews from critics, who dismissed the sexual portrayal of her role.
In her late teens, her rebelliousness played itself out on screen and in print.
Barrymore forged an image as a manipulative teenage seductress, beginning with Poison Ivy (1992), which was a box office failure, but was popular on video and cable.
(In her 2015 memoir Wildflower, she says she talks "like a valley girl" because she grew up in Sherman Oaks.) She moved back to West Hollywood upon becoming emancipated at 14.
In the wake of her sudden stardom, Barrymore endured a notoriously troubled childhood.
She was born into an acting dynasty: All of her paternal great-grandparents – Maurice Barrymore and Georgie Drew Barrymore, and Maurice Costello and Mae Costello (née Altschuk) – as well as her paternal grandparents, John Barrymore and Dolores Costello, were actors; a great-great-granddaughter of Irish-born John Drew and English-born Louisa Lane Drew, all of whom were also actors, and a great-grandniece of Broadway idol John Drew, Jr.